Tag Archives: Liver

Donor liver survives crash en route to transplant – USA TODAY

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YORK, Pa. — An operation for a liver transplant was underway Saturday morning at Thomas Jefferson University Hospital in Philadelphia when Dr. Warren Maley called and said there was a problem.

The SUV transporting Maley, two other people and a preserved liver — on ice and inside a box — had left York Hospital on-time but slid on a slippery road in Lancaster County and crashed, rendering it inoperable, he said.

“We started exploring different options, having an ambulance take us, calling state police,” Maley said.

That’s when East Cocalico Township Police Sgt. Darrick Keppley, who had responded to the crash, stepped up.

“He right away said he would be glad to take us back,” Maley said of Keppley. “That was a godsend, because it meant we only had an hour delay, instead of three or four hours if we had waited for someone to pick us up.”

Liver unharmed in crash

Maley, along with an assistant and a Gift of Life employee, acquired the liver from a patient at York Hospital earlier that morning and then left for Thomas Jefferson in an SUV driven by a transport company contracted by Gift of Life, an organ donor organization, he said.

Citing patient confidentiality, Maley said he could not say very much about the donor or the recipient. Dan Carrigan, York Hospital spokesman, deferred questions about the case to Gift of Life.

Gift of Life’s Randy Presant issued a statement Tuesday, saying it is Gift of Life’s policy not to comment on specific cases to protect the privacy of their donors and recipients. Presant said in the news release that there are more than 5,600 area residents awaiting life-saving organ transplants, with more than 119,000 patients nationwide on the organ transplant waiting list. One organ and tissue donor can save and enhance the lives of up to 75 people.

Maley said the liver, once extracted from the donor, was triple-bagged in a preservative solution, surrounded by ice, placed in a Styrofoam cooler and then put inside a cardboard box.

The box did not sustain any damage, and no one in the vehicle suffered injuries in the crash, which occurred just before 9:30 a.m. Saturday near the Pennsylvania Turnpike.

“They were getting off Route 22 to get on the turnpike and the transport vehicle slid off the roadway,” East Cocalico Township Police Sgt. Chris Progin said.

The SUV then struck a median, disabling the front tire, Progin said.

Maley then called the operating room at Thomas Jefferson, where the operation had already started.

“I think the whole OR was pretty shook up,” both about the crash and the liver, he said.

Lights and siren

Leaving the Gift of Life employee with the driver to wait for a tow truck, Maley and his assistant piled in to Keppley’s cruiser.

“I told the officer I wanted to sit up front because I didn’t want to feel like a perpetrator,” he said. So the assistant sat in the cramped backseat, along with the liver.

Progin said Keppley hit his lights and sirens and took the doctors and the liver onto the turnpike and then to the Schuylkill Expressway to the hospital.

“There are really two heroes in this story,” Maley said, “and that’s the donor and their family and the police officer who drove us down.”

Maley said the operation was a success.

“Everything went very, very well and our recipient’s doing well,” he said.

The crash did give Maley some pause. In 25 years of overseeing organ transplants, he’s never been in a crash.

“It’s something I don’t give much thought to,” he said. “I guess it’s something that we need to think more about.”

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Boy, four, told to have his second birthday early because he was going to die makes miracle recovery after last … – Daily Mail

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  • Byson Bennett, four, received a liver transplant on December 27, 2015
  • The boy’s mother Jasmine was told he wouldn’t be alive for second birthday
  • He was rejected from organ register at 18-months-old because of his illness 

Belinda Cleary For Daily Mail Australia

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The mother of a four-year-old liver transplant patient has described the amazing moment her baby son got a second chance at life. 

Byson Bennett, four, from Christchurch in New Zealand badly needed a new liver from the time he was 18-months old but he couldn’t have one so instead his family were told to say their goodbyes.

His mother Jasmine Bennett remembers the heartache of finding out she might lose her youngest child like it was yesterday.

Jasmine and Byson Bennett before Byson's transplant - he was severely jaundiced before the new liver became available

Jasmine and Byson Bennett before Byson’s transplant – he was severely jaundiced before the new liver became available

Byson, centre, with his brother, Julius and sister Oceanah after the operation

Byson, centre, with his brother, Julius and sister Oceanah after the operation

Byson was born with water on the brain and a liver condition which made it difficult for his body to function

Byson was born with water on the brain and a liver condition which made it difficult for his body to function

‘We went to Auckland and we were told he couldn’t go on the transplant list because the doctors didn’t know if giving him a new liver would make him live another five years, and that was part of the criteria,’ Ms Bennett said.

‘We were told to have his second birthday early because he wouldn’t make it.

‘I still remember the hardest part of being told to go home was knowing that I could lose my son.’

Byson survived past his birthday and continued to exceed doctors’ expectations.

And in May 2015 the family got a phone call to say the criteria had changed and baby Byson could go on the list for a new liver. 

Ms Bennett was over the moon and offered up part of her own liver to her son.

‘I had a few tests and then I was told it wouldn’t work – it was heart breaking,’ she said.

The mother-of-three said the family then waited seven months for a phone call which would change Byson’s life forever. 

The young boy was denied access to a liver transplant when he was 18-months-old - but is doing much better now

The young boy was denied access to a liver transplant when he was 18-months-old – but is doing much better now

‘It came on December 27 at 3am. We were told there was a liver for Byson and we had to be on a plane to Auckland in two hours,’ she said.

‘We were in so much shock but we jumped out of bed, woke up the kids and made it to the airport just in time to get on the plane.’

By the time the family ‘got the call’ Byson had turned a dark shade of yellow as he was suffering from severe jaundice because his liver couldn’t do the job it needed to do.

Just 23 hours after Ms Bennett had woken from the life-saving phone call, Byson was being wheeled out of the operating room at Auckland’s Starship Children’s Hospital.

The Christmas before Byson's transplant - the young boy was notably yellow as his liver struggled to do its job

The Christmas before Byson’s transplant – the young boy was notably yellow as his liver struggled to do its job

He has now had his new liver for just over 12 months and his quality of life improves every day.

‘He must have been in a lot of pain before – because he is developing a lot more quickly now,’ his mother said.

‘He is rolling over, he sings, he talks and he plays with his brother and sister.’

Byson also has a condition known as hydrocephalus – or ‘water on the brain’ – and still relies on Ms Bennett to be tube fed, but is much more independent than he used to be.

'The liver has taken really well ¿ we haven't had any problems yet,' Jasmine said

‘The liver has taken really well – we haven’t had any problems yet,’ Jasmine said

‘The liver has taken really well – we haven’t had any problems yet,’ she said.

‘He is more active now and has so much more energy.’

Not much is known about his brain condition so the busy mum says she just has to ‘wait and see’ as far as his development goes.

‘We do know that he shouldn’t need another liver transplant which is great,’ she said.

Byson turns five on Friday – an amazing achievement for a boy who ‘wasn’t going to make it to his second birthday’, his proud mother said.

Byson is now 'more energetic' and doing some things independently

Byson is now ‘more energetic’ and doing some things independently

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Baby on liver transplant list only waits 40 minutes – KTRK-TV

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CHICAGO, IL (KTRK) —
For adult patients the average wait for a donor liver is about 149 days. For children it’s 86. But for 5-month-old Daniel McCabe and his family – it was a record breaker.Shortly after his birth in July, Daniel was diagnosed with biliary atresia – a rare disorder that causes scarring in the liver and blocks the bile ducts. The infant came to Lurie Children’s Hospital in early December for an evaluation. But soon after his arrival, his condition quickly deteriorated.

“His condition was worsening and becoming dire,” says his mother Melody McCabe.RELATED: Heart transplant gives man second chance at life

The 5-month-old’s best hope for survival was a liver transplant. So on December 13, at 10:15am, Daniel was placed on the wait list for a new organ.

“I think it was the best thing for him. He was deteriorating fairly rapidly, even for this disease. Usually it’s not so fast, and he really needed that liver as soon as possible,” pediatric liver specialist Dr Saeed Mohammed said.

What happened next is hard to believe. Just 40 minutes later, his doctors were notified of a potential match.

“I’ve never seen anything this fast,” Mohammad said.

RELATED: Texas hospital does 4 uterus transplants from live donors“The doctor came into the room and he was very quiet, and it felt like he was quiet for a very long time and I was expecting bad news. And when he said, ‘he has a liver,’ I’m still in shock at how quickly that was,” McCabe said.

Once the donor organ arrived at Lurie Children’s, transplant surgeon Dr. Riccardo Superina carefully divided the adult-sized liver. A small portion was given to Daniel and the remainder went to a patient at another hospital. Not one, but two patients benefited from a single organ in this particular case.

This was all about timing. Just as Daniel’s medical information was posted on the wait list, so was the deceased donor’s. And because Daniel was so sick, he was eligible to be matched very quickly.

Daniel is doing really well but expected to stay in the hospital for several more weeks. The family hopes to go home sometime in February.

(Copyright ©2016 KTRK-TV. All Rights Reserved.)

New model could benefit liver cancer transplant patients – Medical Xpress

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A simple blood test may better predict which patients diagnosed with liver cancer will experience disease recurrence, according to new research from Weill Cornell Medicine scientists. The findings may help physicians determine who would benefit most from a liver transplant.

Depending on disease severity, oncologists may recommend for patients whose tumors have not yet metastasized. Physicians have traditionally used a special set of criteria, based on the size and number of tumors, to assess patients’ risk of cancer reoccurrence if they receive a new organ – the findings from which ultimately determine if transplantation is the appropriate treatment.

In their study, published Sept. 16 in the Annals of Surgery, Weill Cornell Medicine investigators demonstrate that measuring the concentration of molecules in the blood that increase in the presence of can discern which patients will experience disease relapse more effectively than the current model. The scientists say the new criteria, known as the Model of Recurrence After Liver Transplant – or MORAL score – can help ensure that those who are selected for have the best chance of staying cancer-free after surgery.

“At the end of the day, our goal is to use better predictors to provide patients with improved treatment options,” said Dr. Robert Brown, the Gladys and Roland Harriman Professor of Medicine at Weill Cornell Medicine and co-creator of the MORAL criteria. “By using pre-transplant biomarkers focused more on the growth and aggressiveness of liver cancer, we can determine which patients will do better with a liver transplant and which patients would benefit from more aggressive pre-transplant therapies to control their cancer.”

In conjunction with surgeon Dr. Karim Halazun, an assistant professor of surgery at Weill Cornell Medicine, and other surgeons from NewYork-Presbyterian, Brown prospectively studied a cohort of 339 patients with hepatocellular carcinoma who had undergone transplantation to determine whether the MORAL criteria, compared with the traditional Milan criteria, could better predict cancer recurrence. Measuring common blood tests – including the breakdown of the white blood cells, specifically the neutrophil and lymphocytes, and the amount of a tumor marker protein, the alpha-fetoprotein, in the blood – correctly predicted 91 percent of the time, while the Milan criteria only yielded a 63 percent accuracy rate, Brown said.

“Using our MORAL score, we want to help patients lead longer lives,” said Brown, director of the Center for Liver Disease and Transplantation and a hepatologist at NewYork-Presbyterian Weill Cornell Medical Center. “By combining this score with therapies we are developing to selectively change immune suppression in high-risk patients, we would be able to tell the risk of their cancer returning and at the same time tell them we have a plan for reducing that risk – that we can do something about it.”

Explore further: Researchers develop more accurate tool to predict whether liver cancer will recur in transplant patients

Non-profit helping young liver transplant recipient see grandfather – WPXI Pittsburgh

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Updated:

YOUNGSTOWN, Ohio – A Pennsylvania non-profit is asking for help making a little boy’s dream come true.

One year ago, Wyatt Baile underwent a life-saving liver transplant at Children’s Hospital in Lawrenceville. He was just 5 months old at the time of his surgery.

Today, he’s running and talking like other 17-month-old kids.

“Some kids want to go to Disney, some want to go to Hawaii, and I just want him to have memories with his papa,” said Sara Baile, Wyatt’s mother.

Her adoptive father Dennis is a retired police officer who lives in Arizona. The last time Dennis saw Wyatt, he was sick and in pain. 

“All of our pictures, if you look at before transplant with my dad, he’s (Wyatt) almost green. He would cry and cry,” Baile said.

Dennis is dealing with health issues and can’t travel to their home in Youngstown for the holidays. Baile needs to fly to Phoenix to see him.

That’s where Jamie’s Dream Team is stepping in. They’re hoping to raise money to send Baile and her two children to Arizona Dec. 22 through Jan. 2. They’re inspired by Baile, who has given back to others at Children’s Hospital.

“She’s going through all of this moving, so on and so forth, she’s doing a pajama drive for the hospital,” said Jamie Holmes, founder of Jamie’s Dream Team.

The trip is especially important for Baile, who already lost her adoptive mother, sister and a 6-month-old nephew. She wants Wyatt to have pictures with his grandpa that he can cherish for a lifetime.

To donate to help Baile and her family get to Arizona, CLICK HERE.

Seven-year-old Kenzy rushed to London for vital liver transplant – The Courier

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Kenzy is now resting after undergoing his six hour surgery.

A seven-year-old Arbroath boy placed on high priority is recovering after undergoing a much needed liver transplant.

The family of Kenzy Oliver made a frantic trip to London on Friday night after receiving word a suitable replacement organ had been found.

After hopping on an air ambulance from Dundee Airport, Kenzy was checked into hospital where he underwent six hours of surgery.

Kenzy and family received work on Friday evening that a suitable liver had been found.© Supplied

Kenzy and family received work on Friday evening that a suitable liver had been found.
As of this morning, the youngster is recuperating as doctors wait to see how he reacts to his new liver.

Kenzy’s mum Michelle revealed: “That’s Kenzy out of surgery and in recovery, get to see him in half an hour or so.

“Kenzy got a full left side of a liver at a good size that fills most of the space provided.

“He had a full blood transfusion as left cut livers bleed more at the cut but nothing unnormal for his operation and is expected in all kids transplants.

“He is being left in a sleep state for today to minimise any movement and stress to his new liver and should be woken at some point tomorrow.

“So now only time will tell on how it will take and how fast of a recovery he will take.

“His surgery has taken 6/6.25hours to do which is relatively a good time for something so complex.”

Kenzy was born with biliary atresia, a condition in which inflammation develops within the bile ducts around the time of birth. How he contracted it is unknown.

He was placed as a high priority on the transplant list after a check-up at the beginning of the year revealed the liver condition he was born with brought on a serious breathing complaint.

The seven-year-old is the only case Dundee’s Ninewells Hospital has seen with both debilitating ailments, according to his parents.

Model Predicts Portal Vein Thrombosis Risk Before Transplant – Medscape

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BOSTON — Candidates for liver transplantation who are at risk for portal vein thrombosis can be identified with a simple risk model, allowing clinicians to start them on thromboprophylaxis, according to a large database study.

“We looked at patients waiting for liver transplantation who did not have portal vein thrombosis to see what risk factors predicted the development” of a clot in the portal vein, said Abdul Haseeb, MD, MPH, a second-year fellow in gastroenterology, hepatology, and nutrition at the University of Utah School of Medicine in Salt Lake City.

The researchers found that just four variables are strongly predictive of subsequent portal vein thrombosis risk, and the resulting risk score can be used to classify patients as being at low or high risk.

The condition affects an estimated 5% to 16% of patients undergoing evaluation for liver transplantation, and is associated with operative complications and poor clinical outcomes.

“Clinical presentation of portal vein thrombosis can range from a silent finding to a syndrome that includes abdominal pain, gastrointestinal bleeding, lactic acidosis, sepsis, nausea, and vomiting,” Dr Haseeb explained.

The consequences of a small portal vein thrombosis can be minor, but an extensive thrombosis can be a contraindication for transplantation, he said.

Dr Haseeb presented results from the study during a briefing here at The Liver Meeting 2016.

Risk Prediction Model

Dr Haseeb and his colleagues assessed 891 patients with decompensated cirrhosis on the waiting list for liver transplantation who underwent serial ultrasound or other cross-sectional imaging of portal and hepatic vessels from 1987 to 2014.

They divided the group into a derivation cohort of 621 patients (70%) and a validation cohort of 270 patients (30%).

On univariate analysis, the researchers narrowed the 34 variables they considered down to nine independent variables. They then created multivariate regression models and, using the beta coefficients for each variable from the final regression model, created a risk score for portal vein thrombosis with just four variables.

They tested their creation — which they called the Intermountain PVT Risk Score — in the validation cohort.

The four variables determined to be predictive of portal vein thrombosis are a history of bacterial peritonitis, a history of esophageal and/or gastric varices, and, at the time the patient is added to the waiting list, hepatic encephalopathy and a bilirubin level above 4.5 mg/dL.

All variables were assigned 1 point except bilirubin, which was assigned 2 points.

Each patient could have a risk score from 0 to 5, with 5 indicating the highest risk for portal vein thrombosis. A risk score above 3 is associated with a 15-fold risk, Dr Haseeb reported.

Table. Variables Predictive of Portal Vein Thrombosis

Variable Hazard Ratio 95% Confidence Interval P Value
History of bacterial peritonitis 2.58 1.09–6.13 .032
History of esophageal or gastric varices 2.88 1.66–5.00 <.001
Hepatic encephalopathy at list 2.74 1.03–7.34 .044
Bilirubin >4.50 mg/dL at list 3.87 1.96–7.61 <.001

In both the derivation and validation cohorts, the negative predictive value was higher when the risk score was 3 or higher than when the risk score was 2 or lower (94.3% vs 92.3%).

Prospective studies are needed to determine whether interventions on the basis of risk score, such as anticoagulation therapy with warfarin or low-molecular-weight heparin, will reduce the frequency of portal vein thrombosis and improve outcomes for patients on the waiting list, Dr Haseeb noted.

The risk score might have more research value than clinical utility, said Mordechai Rabinovitz, MD, from the division of gastroenterology, hepatology, and nutrition at the University of Pittsburgh Medical Center, who was not involved in the study.

“Everyone who’s going for a transplant is being evaluated closely. Everyone has CT scans, MRI, ultrasound, so if any patients have a portal vein thrombosis, we know about it in advance,” he told Medscape Medical News.

“There are many times when the transplant evaluation was done a year or 2 before,” Dr Rabinovitz explained. “Let’s say today they find a liver for a patient. Everything that was done then doesn’t apply to today, so you need to repeat the tests. This is nice academically, but before transplant, you need to prove if the patient has a portal vein thrombosis or not.”

The study funding source was not disclosed. Dr Haseeb and Dr Rabinovitz have disclosed no relevant financial relationships.

The Liver Meeting 2016: American Association for the Study of Liver Diseases (AASLD): Abstract 238. Presented November 14, 2016.

After childhood liver transplant, Valeria Tokajer is all grown up – FOX 13 News, Tampa Bay

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– People did everything to raise money for little Valeria Tokajer. She needed a liver transplant to stay alive and her parents’ insurance wouldn’t cover the cost.  

They raised funds at football games, wrestling matches, and concerts. When a liver was found, her parents rushed her to Pittsburgh for a transplant, but instead they got devastating news.

“We were told the liver they found for Valerie was too small and they weren’t able to do the transplant,” said Valerie’s father, who was a young Bradenton police officer in 1989, when Valeria got sick.

Now he’s the police chief in nearby Holmes Beach. People still ask about his daughter.

“You can tell that they’re a little hesitant at times because they’re not sure if things continued to go well after the transplant,” says Tokajer.

As it turned out, a liver was finally located. Valerie spent a lot of time in doctors’ offices and the hospital, but the good news is, if you want to know what ever happened to Valerie, you can ask her.

“I have my bachelor’s degree in health care administration and I’ve been married for nine and a half years now,” Valerie said.

She’s now 29 and has a daughter of her own. Her name is Aniston and she’s just about the same age as Valerie when we met her as a 2-year-old so many years ago.

“I’m working at Manatee Memorial Hospital, coincidentally where I was born,” Valerie smiles.

She says she remains grateful to her parents and people across our area who came together to raise money to save her life.

Delhi: World’s smallest baby gets liver transplant – Hindustan Times

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Hindustan Times
Delhi: World’s smallest baby gets liver transplant
Hindustan Times
Doctors at a private hospital in the city transplanted liver in a baby weighing just 2.1 kg — the smallest baby to have such a surgery in the world. To date, the smallest baby to have undergone a liver transplant and survived weighed 2.59 kg and was
Nigerian baby of 2 months undergoes liver transplant in DelhiZee News
2-kg baby undergoes successful liver transplantThe Hindu
Infant weighing just 2.1 kg has liver transplantThe Asian Age
Calcutta Telegraph –Times of India
all 7 news articles »

Organovo unveils bioprinted liver transplant patches – Mass Device

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Mass Device

Mass Device
Organovo (PINK:ONVO) today announced it is developing 3D bioprinted human liver tissue designed for direct transplantation to patients. The move to human development comes based on “strong results” from preclinical animal model studies, the San Diego …
Organovo to make liver tissue for transplant; Meeting on the Mesa beginsThe San Diego Union-Tribune
Organovo Plans to Develop 3D Bioprinted Human Liver for Transplant3DPrint.com